Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures

Abstract

To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.