Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer’s Disease Severity

Abstract

Introduction: Inflammatory processes and neurodegeneration are common features of Alzheimer's disease (AD). The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are easily accessible, cost-effective prognostic indicators of inflammation status. We assessed the diagnostic value of SII and compared the efficacies of NLR, PLR, and SII in predicting AD severity. Materials and Methods: Between January 2021 and December 2022, this prospective, cross-sectional clinical study included 175 patients with AD and 61 controls. SII, NLR, and PLR were calculated. Results: Age, white blood cell and lymphocyte counts, and NLR and PLR values were significantly different between the patient and control groups (P