Effect of Gender Related Differences on Cerebral Oxygen Saturation

Abstract

Background: The present study was conducted to evaluate the cerebral oxygen saturation (rSO2) difference between female and male patients before induction of anesthesia and during anesthesia in neurosurgical procedures. Methods: A total of 120 patients scheduled for elective neurosurgeries were enrolled in this prospective cohort study. SpO2, end tidal CO2 (EtCO2), and bilateral frontal rSO2 values were recorded during (1) the baseline (BL), (2) after raising FiO2, (3) after induction of anesthesia (Ind), (4) after tracheal intubation (after intub), (5) before positioning (pre-pos), and (6) after positioning for each patient at 1, 5, 15, 30, and 60 minutes after positioning. Results: A total of 111 patients were included for statistical analysis; of whom 59 were female and 52 were male. The mean age was 45.2 years for women and 47.7 years for men. Hemoglobin concentration was statistically lower in female patients. (12.5 +/- 1.3 vs 13.6 +/- 1.3, P value < 0.05). The measured values of rSO2 in every recorded time showed a statistically significant difference in rSO2 values between female and male patients from the baseline (BL) until 60 minutes after positioning. There was not any significant correlation between age and rSO2 (r =-0.003, P = 0.997) or BMI and rSO2 (r = 0.05, P = 0.965). No significant difference was obtained between right and left side rSO2. Conclusions: This study revealed that even after reducing the confounding role of hemoglobin, measured values of rSO2 were lower in the female group undergoing neurosurgical procedures.Copyright © 2018, Archives of Neuroscience.