Chemical characterization and bio evaluation of cinnamon (Cinnamomum verum) extract against glycated haemoglobin and hyperglycemia in human female subjects with polycystic ovarian syndrome

Abstract

Polycystic ovarian syndrome, in which females have high androgen levels, causes reproductive difficulties, insulin resistance, hyperglycemia, weight gain, irregular reproductive cycles, and hormonal imbalance. Cinnamon sticks reduce insulin resistance and hyperglycemia. This study examined how cinnamon stick powder affected hyperglycemia in polycystic ovarian syndrome women. Treatment groups I and II received 250mg and 500mg encapsulated cinnamon stick powder. 45 ladies with polycystic ovarian syndrome had their random, fasting and HbA1c assessed on days 0 and 60. All results were analyzed using a two-sample t-test with the help of software IBM SPSS Statistics 20 version. It contained moisture at 24.1%, ash at 17.82%, nitrogen-free extract at 36.12%, crude protein at 8.32%, crude fiber at 6.98% and crude fat at 6.87%. Means for minerals in mg/g were zinc 2.37mg, iron 0.69mg, chromium 0.31mg, calcium 83.28mg, magnesium 23.17mg, sodium (0%), manganese 21.01mg, phosphorus 43.01mg and potassium 133.87mg were determined. The cinnamon powder contained 20.12mg gallic acid equivalent of total phenolic content and 2.73mg quercetin equivalent of total flavonoid content. Treatment groups showed significant (p<0.05) reduction in blood sugar levels and glycated hemoglobin in response to the cinnamon oral dose. Treatment group II showed better results as compared to treatment group I at a higher dose of 500mg.