Pregabalin

Abstract

Pregabalin is a newer generation gabapentinoid and is structurally similar to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Gabapentin was initially synthesised over forty years ago as an adjuvant antiepileptic drug but has since become widely prescribed to treat neuropathic pain. Similarly, pregabalin use in epilepsy is limited and its use has been targeted for the treatment of neuropathic pain.