p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

Abstract

The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development. © 2010 Landes Bioscience.