Comparison of in vitro antimicrobial susceptibilities of Mycobacterium avium-M. intracellulare strains from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and animal sources

Abstract

Difloxacin, A-56620, cefazolin, cefotaxime, ceftizoxime, cephapirin, SK and F 88070, and spectinomycin were used to compare the in vitro susceptibilities of Mycobacterium avium-M. intracellulare isolates from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and diseased animals. Against the isolates from humans without AIDS, the quinolone compounds difloxacin and A-56620 were found to be the most effective, each inhibiting 50% of strains at a concentration of 2 μg/ml. The remaining antimicrobial agents head MICs for 50% of strains tested of at least 32 μg/ml. Statistically significant differences were observed in the antibiogram patterns among the M. avium-M. intracellulare strains from each of the three sources.