Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins

Abstract

Peptides are of growing interest as a non-immunoglobulin alternative for the development of new molecular entities. Disulfide-stabilized miniproteins are a class of peptides that represent an ideal template for the development of stable affinity reagents in drug design, molecular diagnostics, and targeted therapy. This is due to their outstanding proteolytic stability, their small size, and especially their tolerance to mutagenesis. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.