Zn(yii) chloride-catalyzed direct coupling of various alkynes with acetals: Facile and inexpensive access to functionalized propargyl ethers

Abstract

The coupling of acetals with various alkynes was achieved using only 1 mol% of inexpensive and mild Lewis acid ZnCl2, which furnished propargyl ethers. The coupling was catalyzed by Zn(OMe)Cl, which was generated in situ to form an alkynylzinc species. This protocol was allowed to expand to a one-pot subsequent reaction with allylchlorosilane to obtain a 1,4-enyne product. © 2013 The Royal Society of Chemistry.