Inhibitory Effects of Green Tea Polyphenol on Glucan Synthesis and Cellular Adherence of Cariogenic Streptococci

Abstract

Inhibitory effects of green tea polyphenols on glucan synthesis by glucosyltransferases of Streptococcus mutans MT8148 and Streptococcus sobrinus 6715DP and on sucrose-dependent adherence of the bacterial cells were examined in vitro. The glucan synthesis by the bacterial glucosyltransferase was strongly inhibited by (—)-epicatechin gallate (ECg) and (—)-epigallocatechin gallate (EGCg), the main components of the tea polyphenols. It was also demonstrated that ECg and EGCg interfered with the sucrose-dependent adherence of those bacterial cells at much smaller concentrations than those which were needed to inhibit the growth of the bacteria. © 1990, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.