The Role of IL6, IL8, TNF α, INF α and some of the positive acute-phase protein in the prognosis of SARS COVID-19

Abstract

A case-control study was conducted in the AL HUSSAIN hospital in Thiqar governorate from February 2020 to July 2020. A total of 188 individuals involved in the current study, 94 of them with SARC COVID 19 infected patients, and 96 health as controls were enrolled in this study. Serum was collected from each of them to assess the levels of The IL6, IL8, TNFα, INFα, ferritin, D- dimer, LDH, CR protein. Evaluation of cytokine concentrations in patients and control groups was done by ELISA kits according to the manufacture’s instruction. The concentration of serum interleukinsIL1RA, IL2, IL6, IL8, TNFα, INFα and the serum concentration of ferritin, D.dimer, LDH, CR protein were measured in patients and control groups. The mean of IL6, IL8, TNFα, INFα concentration were higher inpatients than the control group with statistically significant differences (P-value 0.00). The Serum concentrations of ferritin, D.dimer, LDH, CR protein (684.4, 0.9, 536.7, and 29.9) were higher than the normal range respectively.