Impaired priming on the general knowledge task in amnesia

Abstract

The status of priming on the general knowledge test was examined in amnesia. Twenty amnesic and 20 control participants studied words (e.g., CHEETAH) under semantic and nonsemantic encoding conditions and attempted to answer general knowledge questions (e.g., 'What is the fastest animal on earth'?) under implicit and explicit retrieval instructions. The measure of memory was how many more test questions participants answered correctly using studied than nonstudied words. Amnesic patients showed impaired memory under implicit and explicit retrieval instructions. Control participants showed equal memory under implicit and explicit retrieval instructions, a result indicating that they engaged in explicit retrieval in both instruction conditions. General-knowledge priming appears to involve explicit retrieval that depends on medial-temporal and diencephalic regions damaged in amnesia.