Neuromyelitis optica spectrum disorder with active replication of hepatitis B virus and seropositive anti-Aquaporin-4 antibody A case report

Abstract

Rationale: Neuromyelitis optica spectrum disorder (NMOSD) associated with active replication of hepatitis B virus (HBV) is rare. High-dose corticosteroids are the mainstay treatment of NMOSD; however, these may cause reactivation of viral replication in patients with stable HBV which may lead to liver damage. Therefore, care should be placed in corticosteroid use in patients with NMOSD and HBV infection. Patient concerns: Herein, we report the case of a 31-year-old woman with NMOSD and HBV infection who was seropositive for anti-Aquaporin-4 antibody. The stable and HBV carrier status of the patient led to the deferment of antiviral and hepatoprotective agents in early treatment. However, liver function impairment was detected during follow-up, with an improvement in the bestcorrected visual acuity. Diagnoses: The patient was diagnosed with NMOSD with active replication of HBV and seropositive anti-Aquaporin-4 antibody considering the medical history and ancillary examinations. Interventions: To manage NMOSD, intravenous high-dose methylprednisolone (20mg/kgd) was administered for 5 days which was gradually tapered to oral steroids. However, liver function impairment was observed during follow-up; therefore, anti-HBV drugs (entecavir) and hepatoprotective drugs (bicyclol or polyunsaturated phosphatidylcholine) were administered. Outcomes: A marked improvement was observed in the patient s best-corrected visual acuity after 4weeks of treatment. However, follow-up examinations revealed liver function damage which necessitated administration of antiviral and hepatoprotective drugs. Liver function normalized after 1month. Lesson: This case underscores the importance of preventive treatment of liver protection in patients with HBV infection prior to or simultaneous with glucocorticoid therapy and furthermore, there is an urgent need to develop authoritative guidelines regulating corticosteroid use in the treatment of patients with HBV infection. Abbreviations: AQP4-Ab = seropositive anti-Aquaporin-4 antibody, CHB = chronic hepatitis B, CNS = central nervous system, HBV = hepatitis B virus, NMO = neuromyelitis optica, NMOSD = neuromyelitis optica spectrum disorder, ON = optic neuritis.