Microbial resistance to colistin in consequence of mutations in the MCR-1 gene of Escherichia coli

Abstract

Objective: To evaluate the current situation of microbial resistance to colistin caused by mutations in the MCR-1 gene in Escherichia coli. Materials and methods: A systematic review of the literature was carried out using scientific papers published in Scielo and Pubmed database since 2000. Results: The plasmid-mediated colistin resistance MCR-1 gene is a transmissible gene that causes lipopolysaccharide modifications by regulation systems, presented on chronological scale to the inactivation of drugs that interact with the phospholipids and disorganize the structure of the cell membranes due to the indiscriminate use of colistin. Microbial resistance is mostly related to chromosomal mutations, however, when it refers to colistin it often occurs through horizontal gene transfer. Conclusion: Whereas the mechanisms of microbial resistance to colistin it was possible to conclude that microbial resistance is mostly related to chromosomal mutations, however, when it refers to colistin it often occurs through horizontal gene transfer by plasmid