Journal ArticleOPEN ACCESS

Identification of new natural CphA metallo-β-lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from municipal sewage in central Italy

Antimicrobial Agents and Chemotherapy (2015) 59(8) 4990-4993
DOI: 10.1128/AAC.00628-15
16Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Two new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems only. CphA5 showed kcat values about 40-, 12-, and 97-fold higher than those observed for CphA4 versus imipenem, ertapenem, and biapenem, respectively.

Cite

CITATION STYLE

APA

Bottoni, C., Marcoccia, F., Compagnoni, C., Colapietro, M., Sabatini, A., Celenza, G., … Perilli, M. (2015). Identification of new natural CphA metallo-β-lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from municipal sewage in central Italy. Antimicrobial Agents and Chemotherapy, 59(8), 4990–4993. https://doi.org/10.1128/AAC.00628-15

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free