Ferroptosis and cancer: Physiopathological and therapeutic implications

Abstract

Ferroptosis is a process leading to cell death. The final event is the lethal accumulation of peroxidized lipids. Iron is at the center of the reactions leading to the formation of peroxidized lipids, while an antioxidant system is dedicated to the detoxification of these lipids to prevent cell death. Ferroptosis is involved in many human diseases, including the pathophysiology of neurodegenerative diseases, infection, and cancer. We will present the different cellular actors that control ferroptosis and propose a review of current data involving this cellular process in cancer.