Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder

Abstract

This study highlights the importance of investigating dynamic intrinsic brain activity in patients with bipolar disorder (BD) during different mood states. The patients with euthymic BD showed significantly less flexibility of temporal functional activities in the left and right cerebellum posterior lobe compared to patients with depressed BD or healthy individuals. The use of dynamic fractional amplitude of low-frequency fluctuations and dynamic degree centrality allowed for a comprehensive analysis of brain activity, providing reliable and objective results.