Organometallic polysynthons: A novel strategy for selectively polyfunctionalized molecules

Abstract

An account is given of our exploratory work on metallometalation of unsaturated systems, which relies on: a) Regio- and stereoselective silyl- and stannyl-cupration of N-containing unsaturated molecules such as propargylamines, ynamines, and isocyanates; b) Silyl- and stannyl-cupration of α,β- unsaturated acylsilanes. The generation and synthetic utility of the nucleophilic polysynthons related to dimetallic adducts, are highlighted and preliminary results on the application of this methodology in chemo-,regio- and stereoselective reactions is presented. © 1992 IUPAC