Spina bifida in Saudi Arabia: Is consanguinity among the parents a risk factor?

Abstract

Introduction: Spina bifida is an important birth defect. Its incidence differs from one country to another due to different factors. The aims of this study were: (1) to estimate the incidence of spina bifida in Al-Madinah Al-Munawarah and compare it with the Eastern part of the Kingdom, and (2) to find out if consanguinity is a risk factor. Methodology: A prospective study was conducted over the period from April 1996 to March 1997 in the city of Al-Madinah Al-Munawarah, Western Province, Saudi Arabia. New cases of spina bifida were studied and compared to a control group of 72 cases. Results: During the study period, 18 cases of spina bifida were detected. The incidence was 1.09 per 1,000 live births. The male to female ratio was 2:1; however, this was not statistically significant. Consanguinity of the parents was found in 89% of the spina bifida parents and only 67% of the controls (p < 0.0005). Conclusion: (1) The incidence of spina bifida in the city of Al- Madinah Al-Munawarah was similar to that reported from the Eastern Province of Saudi Arabia. (2) The consanguinity of the parents was a significant risk factor. Copyright (C) 2000 S. Karger AG, Basel.