One-pot synthesis of 1,8-dioxodecahydroacridines and polyhydroquinoline using 1,3-Di (bromo or chloro)-5,5-Dimethylhydantoin as a novel and green catalyst under solvent-free conditions

Abstract

Solvent-free, one-pot synthesis of polyhdroquinoline and 1,8-dioxodecahydroacridine derivatives have been described via Hantzsch condensation of various aldehydes, ammonium acetate with (i) cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate and (ii) cyclic 1,3-dicarbonyl compounds (2 mmoles) in a very simple, efficient, and environmentally benign method using 1,3-(dibromo or dichloro)-5,5-dimethylhydantoin as a cheap, non-toxic and neutral catalyst with up to excellent yields. © 2013, Sociedad Química de México.