Anti-inflammatory Activity of Andong Leaf Extract (Cordyline Terminalis Kunth) Against Edema in the Soles of Wistar Rats

Abstract

The Balinese plant andong (Cordyline terminalis Kunth) has anti-inflammatory properties. The focus of this research was to determine whether andong leaf extract has anti-inflammatory properties and is effective against carrageenan-induced edema in rat soles. In this study, carrageenan was used to induce inflammation in the soles of Wistar rats. 25 rats were divided into five treatment groups. Group I was given aquadest as the control; group II was given diclofenac sodium at a dose of 4.5 mg/kgbw as a drug control; and groups III, IV and V were given ethanol extract of andong leaves at doses of 150 mg/kgbw, 300 mg/kgbw, and 600 mg/kgbw orally as test groups. For six hours, the inflammation volume was measured using a plethymometer. One-way ANOVA was used to test differences between the treatment groups. The results showed that the ethanol extract of andong leaves had the highest anti-inflammatory activity in the six-hour period when given at doses of 150 mg/kgbw (36.35% 0.02), 300 mg/kgbw (26.30% 0.20), and 600 mg/kgbw (20.67% 0.16) with a significant difference (p < 0.05) compared to the negative control (86.84% 0.092), but this was not significantly different from the positive control (22.21% 0.01). Based on these findings, it can be concluded that a dose of 600 mg/kgbw is the most effective in reducing inflammation. Keywords: Anti-inflammatory, Red andong leaf, Carrageenan, Wistar rat, Edema