Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review

Abstract

Pyrimidine is an aromatic and heterocyclic organic compound containing a 6-membered ring consisting of four carbon and two nitrogen atoms on an alternative position. Pyrimidine scaffolds described its existence between the medicinal chemist's cause of its synthesizing practicability and nonpoisonous nature. However, the reason behind the neurological disorder is still an open challenge in scientific research and development organizations. Despite high throughput research in the field of anti-Alzheimer's drugs, the efficacy void is quite common before the researchers. Researchers have constantly investigated all the probabilities to restraint the unwanted adverse effects of the anti-Alzheimer's agents or focusing on a more considerable perspective to decline or rehabilitate neurological disorder. The drug development has revealed aspiration to medicinal chemists and researchers to felicitate research by look over through a considerable literature survey. Therefore, the SAR study-based approach has been emphasized that pharmacological advancements of Pyrimidine moiety in the new era as therapeutics anti-Alzheimer's agents.