A Novel Testosterone 5α-Reductase Inhibitor, 8’,9’-Dehydroascochlorin Produced by Verticillium sp. FO-2787

Abstract

A new testosterone 5a-reductase inhibitor, 8’, 9’-dehydroascochlorin, was isolated from the cultured mycelium of Verticillium sp. FO-2787. This compound (M.W.: 402, C23H27C104) consists of 5-chloroorcylic aldehyde and 2,3,4-trimethylcyclohexenone moieties, which are connected via a chain of (2E,4E)-3-methyl-2,4-pentadiene. The IC50 value of the new microbial metabolite for testosterone 5a-reductase activity prepared from rat prostate was 4X10-4M. © 1994, The Pharmaceutical Society of Japan. All rights reserved.