Assessing of funegreek (Trigonella foenum-graecum) seeds pharmacological effects against glucotoxicity and lipotoxicity in streptozotocine-induced diabetic rats

Abstract

Diabetes mellitus is a common disease, treated either with insulin or oral antidiabetics which have undesirable effects because of their chemical composition. As an alternative, diabetes should be treated by medicinal plants. This study aimed to assess the effects of fenugreek (Fng) seeds aqueous extract on biochemical parameters in streptozotocine-induced diabetic rats. A population of forty rats was divided into 4 groups; normal control, diabetic rats by STZ, diabetic treated with Fng at the dose 1 mL (0.5 g / kg) and non-diabetic treated (ND-Fng). During 30 days of experiments, body weight and biochemical parameters were measured and statistically analyzed using SigmaPlot software. No significant difference in body weight was observed in diabetics animal (DC) (168 ±8.5 g/L) and diabetic treated with Fng (167 ± 4.6 g/L). Significant decrease in blood glucose (1.16 ± 0.1 g/L), triglycerides (0.64 ± 0.2 g/L), serum urea (0.38 ±0.1 g/L) and creatinine (8.02 ± 2.8 mg / L) levels were reported in diabetics treated with TFG compared to diabetic animals non-treated. Fenugreek, or Trigonella foenum-graecum, was able to regulate and maintain glycaemia and lipid profile at normal levels at diabetic animals. Introduction