The Role of Momordica charantia in Reducing the Level of Glucose in Mice

Abstract

The effects of aqueous and alcoholic extract (Momordica charantia) on the level of serum glucose were studied on 40 mature males distributed into 5 equal groups and fed basal diets. Group (1) was kept as control negative (fed on basal diet), while the other 4 groups were subcutaneously administered a single dosage of alloxan to induce experimental diabetes. Group (2) was left as a control positive group (diabetes) while the other groups (3), (4) and (5) were orally given Momordica charantia once a day at a dosage of 0.10, 0.20 and 0.40 mg/ml respectively, for 10 days. At the end of the experiment, blood samples from all mice were collected for a biochemical analysis. The results had an effect on the glucose level of the serum, at 0.30mg/ml of water extract of Momordica charantia. On the other hand, there are no effects on the glucose level at the higher dosages of Methanolic Momordica charantia extract.