Persistent unilateral tibialis anterior muscle hypertrophy with complex repetitive discharges and myalgia: Report of two unique cases and response to botulinum toxin

Abstract

Unilateral enlargement of the tibialis anterior muscle associated with complex repetitive discharges occurred over several months in two patients and was preceded by pain and numbness in the lower leg. Neuroradiologic investigations excluded a compressive radiculopathy, but pharmacologic and neurophysiologic studies suggested a neurogenic basis for the muscle hypertrophy. Botulinum toxin A injection into the hypertrophied muscles led to a decreased muscle volume and cessation of muscle pain. © 1992 American Academy of Neurology.