Survival Outcomes and Prognostic Factors of Dermatofibrosarcoma Protuberans: A Population-Based Retrospective Cohort Analysis

Abstract

BACKGROUNDLimited information is available regarding survival outcomes and risk factors of dermatofibrosarcoma protuberans (DFSP).OBJECTIVETo investigate the clinicopathologic characteristics and survival outcomes of DFSP.MATERIALS AND METHODSThe study cohort (7,567 patients) was selected from the Surveillance, Epidemiology, and End Results Program (2000-2018). Demographic and clinicopathologic variables, survival outcomes, and prognostic factors were analyzed.RESULTSA total of 5,640 (74.53%) and 1,927 (25.47%) tumors were located in the skin and soft tissue, respectively. The median follow-up duration was 92 months. Median follow-up times were similar between patients with lymph node (107 months) and distant (102 months) metastases; the median survival time of the 89 patients (1.18%) who died of DFSP was significantly short (41 months, p