A mad partner for Shugoshin in meiosis

Abstract

The centromeric cohesin protector Shugoshin (Sgo) and the spindle checkpoint protein Mad2 are known to act in distinct pathways for ensuring accurate chromosome segregation during eukaryotic cell division. In this issue of The EMBO Journal, Orth et al (2011) describe an unexpected physical interaction between vertebrate Sgo and Mad2, as well as indications of their potential mutual regulation in meiosis. © 2011 European Molecular Biology Organization | All Rights Reserved.