HINT: a database of annotated protein-protein interactions and their homologs

Abstract

Despite the abundance of protein-protein interaction databases currently available online, a source that identifies and lists similar interactions in different species is lacking. The Homologous Interactions (HINT) database is such a collection of protein-protein interactions and their homologs in one or more species. The interactions and their homologs are annotated with Eukaryotic Cluster of Orthologous Groups (KOG) IDs, InterPro domains, Gene Ontology (GO) terminology and Protein Data Bank (PDB) structures. HINT is available as an interactive Web server at http://helix.protein.osaka-u.ac.jp/hint/.