Synaptic Synthesis, Dephosphorylation, and Degradation

Abstract

Background: Although associated with intellectual disability, CDKL5 functions and regulation are poorly understood. Results: Upon neuronal activation, CDKL5 is dynamically regulated through local synthesis, dephosphorylation, and degradation. Conclusion: Neuronal activity and maturation control CDKL5 phosphorylation state and expression. Significance: This is the first report showing the activity-dependent modulation of CDKL5 in the neuronal periphery, further linking it to synapse development and plasticity.