Abstract
Background: Brief coronary artery occlusions (CAOs) protect both the artery's own perfusion territory ('myocardial preconditioning') and adjacent 'virgin' myocardium. Whether ischemia in remote organs protects myocardium is unknown. We examined whether brief occlusion of the anterior mesenteric artery (MAO) or left renal artery (RAO) protects against myocardial infarction. Methods and Results: Area at risk (AR) and infarcted area (IA) were determined in anesthetized rats after 180 minutes of reperfusion following a 60-minute CAO. At normothermia (body temperature, 36.5°C to 37.5°C), IA/AR was 68±2% (mean ±SEM, n= 11) in control rats and 50±3% (n=9, P
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Gho, B. C. G., Schoemaker, R. G., Van den Doel, M. A., Duncker, D. J., & Verdouw, P. D. (1996). Myocardial protection by brief ischemia in noncardiac tissue. Circulation, 94(9), 2193–2200. https://doi.org/10.1161/01.CIR.94.9.2193
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