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A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Cell Reports (2019) 29(1) 62-75.e7
DOI: 10.1016/j.celrep.2019.08.073
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Abstract

Wojnarowicz et al., describe the identification, by an in silico screen, and characterization of a small molecule, AGX51, that targets Id proteins. AGX51 treatment of cells lead to Id protein degradation, cell cycle arrest, and reduced cell viability. AGX51 inhibited pathologic ocular neovascularization in mouse models, phenocopying genetic Id loss.

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Wojnarowicz, P. M., Lima e Silva, R., Ohnaka, M., Lee, S. B., Chin, Y., Kulukian, A., … Benezra, R. (2019). A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Reports, 29(1), 62-75.e7. https://doi.org/10.1016/j.celrep.2019.08.073

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