Abstract
Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Feng, L., Fong, K. W., Wang, J., Wang, W., & Chen, J. (2013). RIF1 counteracts BRCA1-mediated end resection during DNA repair. Journal of Biological Chemistry, 288(16), 11135–11143. https://doi.org/10.1074/jbc.M113.457440
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