Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion correlated with sequential elevation of MIC

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Abstract

Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Saraya, T., Tanabe, K., Araki, K., Yonetani, S., Makino, H., Watanabe, T., … Goto, H. (2014). Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion correlated with sequential elevation of MIC. Journal of Clinical Microbiology, 52(7), 2709–2712. https://doi.org/10.1128/JCM.03593-13

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