Quinolidomicins a1, a2 and b1, novel 60-membered macrolide antibiotics II. Structureelucidation

Abstract

The structures of novel macrolide antibiotics, quinolidomicins Al5 A2and Bls were elucidated as shown in Fig. 1 by NMRspectral analysis including a variety of two-dimensional techniques. The quinolidomicins possess a novel 60-memberedmacrolide ring, which is to our knowledge the largest amongnatural products. © 1993, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.