Organelle contacts: Sub-organelle zones to facilitate rapid and accurate inter-organelle trafficking of lipids

Abstract

When one person wants to communicate securely with another, he/she should contact the other person directly. This rule applies not only to human society, but also to the intracellular micro-society. In the past two decades, it has become increasingly clear that the sub-organelle regions called membrane contact sites (MCSs) are pivotal for inter-organelle transport of lipids in cells, as highlighted in the thematic review series “Interorganelle trafficking of lipids” held in Traffic in 2014–2015. In this commentary, we will describe how the currently prevailing model for lipid trafficking at MCSs was generated, and comment on three important issues that have not been explored: (a1) the principles guiding the generation of an asymmetrical inter-organelle flow of lipids in cells, (b2) the advantages in lipid trafficking at organelle contacts, and (c3) the dynamic network of inter-organelle lipid trafficking.