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Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

  • Cai T
  • Lei Q
  • Yang B
  • et al.
Regenerative Biomaterials (2014) 1(1) 27-35
DOI: 10.1093/rb/rbu010
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Abstract

A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

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APA

Cai, T.-T., Lei, Q., Yang, B., Jia, H.-Z., Cheng, H., Liu, L.-H., … Zhang, X.-Z. (2014). Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release. Regenerative Biomaterials, 1(1), 27–35. https://doi.org/10.1093/rb/rbu010

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