Synthesis and characterization of schiff base complexes of o-vanillin and anthranilic acid and their biological evaluation

Abstract

Complexes of Schiff base derived from o-vanillin (2-hydroxy-3-methoxybenzaldehyde) and anthranilic acid (2-aminobenzoic acid) has been used for complexation with Mn(II), Fe(II) and Co(II). The complexes have been formulated as [ML2X2] where X = pyridine or α-picoline on the basic of their microanalysis. Infrared spectral study has been made to confirm the coordination sites of the Schiff base. The magnetic susceptibility and electronic spectral study leads to tetragonally distorted octahedral symmetry (T4h) of complexes. Their biological evaluation with different strains of bacteria suggest that the complexes are more active than the ligand against both Gram-positive and Gram-negative bacteria.