A molecular “screw-clamp”: Accelerating click reactions in miniemulsions

Abstract

The interface as a “screw clamp”: the copper-free 1,3-dipolar azide–alkyne cycloaddition at the interface of nanodroplets in miniemulsions was studied in detail by NMR spectroscopic methods. The reaction at the oil–water interface proved to exhibit higher rate constants, increased molecular weights and high regioregularity compared to the reaction in solution. © 2014 The Royal Society of Chemistry.