Abstract
One of the most facile routes to prepare carboxylate-substituted imidazolines is by the palladium-catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core (se scheme).
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Dghaym, R. D., Dhawan, R., & Arndtsen, B. A. (2001). The use of carbon monoxide and imines as peptide derivative synthons: A facile palladium-catalyzed synthesis of α-amino acid derived imidazolines. Angewandte Chemie - International Edition, 40(17), 3228–3230. https://doi.org/10.1002/1521-3773(20010903)40:17<3228::AID-ANIE3228>3.0.CO;2-Q
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