Correlation between glycaemic control and lipid profile in type 2 diabetes mellitus patients

Abstract

Background: Patients with type 2 diabetes have increased prevalence of the dyslipidemia. A timely intervention to normalize these circulating lipids might reduce chances of the cardiovascular diseases. Glycated Hb (HbA1c) is an indicator of glycemic status over long term. This study was conducted to find the association between glycemic control and lipid profile in patients with type 2 DM. In developing countries like India, fast industrialization and modern lifestyle is causing more number of DM patients daily. Type 2 diabetes mellitus is often associated with abnormalities of lipids which give rise to the increased incidence of micro vascular and macro vascular complications. We evaluated total 100 diabetic patients with type 2 DM visiting our department in a tertiary care hospital and medical college. HbA1c levels were used for classification of patients into good (< 6.5) and poor (≥ 6.5) glycaemic control and for comparing different lipid profile parameters in our study. There was significant association between the age and HbA1c levels (p < 0.05). There was significant association between the duration of diabetes and HbA1c levels (p < 0.05). Mean HbA1c level in study population was 8.42 ± 1.23, showing overall poor glycaemic control in our study population, similarly the mean levels of lipids show a deranged pattern. Very strong correlation was seen between FBS levels and HbA1c (p<0.0001). Positive correlation was seen between HbA1c levels and Total Cholesterol, LDL and VLDL while negative correlation was seen between HbA1c and HDL levels. The study concludes that to maintain good lipid profile and prevent further cardiovascular complications, better sugar control is required.