Cutaneous sarcoidosis developing after treatment with pegylated interferon and ribavirin: A new case and review of the literature

Abstract

Sarcoidosis is a multisystem granulomatous disease that affects multiple organs in adults between 20 and 50years old. Interferon alpha (IFN-α) is an immunomodulator that has been used in a wide range of diseases, including hepatitis C virus infection, multiple sclerosis, and other types of neoplasias, including leukemia, lymphoma, Kaposi's sarcoma, and melanoma. Standard IFN-α-induced sarcoidosis has been reported, but there are few reports of cutaneous sarcoidosis with pegylated IFN-α therapy. We present a new case of cutaneous sarcoidosis after treatment with pegylated IFN, and a review of the literature. © 2011 The International Society of Dermatology.