The role of apoptosis in the pathology of pancreatic cancer

Citations of this article
Mendeley users who have this article in their library.


Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer. © 2010 by the authors; licensee MDPI, Basel, Switzerland.




Samm, N., Werner, K., Rückert, F., Saeger, H. D., Grützmann, R., & Pilarsky, C. (2011, March). The role of apoptosis in the pathology of pancreatic cancer. Cancers.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free