Some Attempts to Produce an Experimental Vaccine with Rhinoviruses

Abstract

When tissue-culture fluid containing live-tissue culture-passed P.K. virus was administered to five volunteers intranasally, some developed symptoms of the common cold and had rises in serum neutralizing antibody; it was administered orally to 14 volunteers who remained symptom-free and had no antibody rises. P.K. virus, either live or inactivated by formalin or by heating We conclude that it is now necessary to try to improve the antigenic potency of tissue-culture material and to determine whether it can induce immunity to experimental colds. If it does it may still be very difficult to find virus strains which will give a useful degree of protection against natural colds. at 37° C. for three days, when given as an intramuscular injection produced no symptoms and induced homologous antibody responses in volunteers. Heterologous antibody responses to B632 virus were induced by an E.C.H.O. 28 formolized vaccine; P.K. vaccine induced no antibody responses to either of these viruses. © 1963, British Medical Journal Publishing Group. All rights reserved.