Daily concurrent CHEMORADIOTHERAPY with DOCETAXEL (doc) and CISPLATIN (cddp) using SUPERSELECTIVE intra-arterial infusion via the superficial temporal artery for stage iii and iv oral cancer-possibility of organ preservation in advanced oral cancer-

Abstract

Superselective intra-arterial chemotherapy via the superficial temporal artery has become feasible for daily concurrent radiotherapy and chemotherapy for head and neck cancer. This novel method was used for oral cancer, and its efficacy was evaluated. Treatment consisted of superselective intra-arterial infusions (DOC total 60 mg/m2, CDDP total 100 mg/m2) and concurrent radiotherapy (total 40 Gy) for four weeks as preoperative therapy. Thirty-four patients with stage III and IV oral cancer received surgery after this treatment, and pathological CR was obtained in 31 patients (91%). The possibility of organ preservation for advanced oral cancer was evaluated from this result. Patients with oral cancer stage III and IV were treated for four-week daily concurrent chemoradiotherapy, and the clinical response was evaluated after treatment. Clinical CR of primary sites was obtained in 15 patients, and the same treatment was continued one or two weeks. Thirteen patients (80%) were disease-free in the primary sites, and two (20%) relapsed. Two patients died of distant metastasis, and one died of local recurrence. This method can preserve organs and minimize functional disturbance, thus contributing to patient QOL. © 2006, Japan Society for Head and Neck Cancer. All rights reserved.