Interferon and PV stem cells

Abstract

IFN-α resuscitates normal dormant hematopoietic cells suppressed by the polycythemia vera clone and induces polyclonal hematopoiesis.1,2 Is the mechanism of this salutary effect mediated by augmentation of immune attack against the mutant clone, by direct suppression of the mutant clone via altering its cytokine signaling, or by a direct effect on clonal and normal stem cells?