Mechanismen des Neuritischen Prunings

Abstract

The axons, dendrites and synapses of neurons are among the most intricate structures cells can build. Their morphogenesis involves growth mechanisms, but also regressive mechanisms like retraction or degeneration of supernumerary or non-specific processes. Regressive mechanisms are collectively known as pruning. Pruning can serve the specification of neuronal circuits or the removal of developmentally intermediate structures. Pruning can affect both single synapses or long stretches of neurite. Here, we introduce well-characterized models of developmental pruning in mammals and Drosophila with their presumed purpose, triggers and cell biological mechanisms. We will then define general mechanistic features of pruning.