Nucleic-Acid-Templated Synthesis of Smart Polymer Vectors for Gene Delivery

Abstract

Nucleic acids are information-rich and readily available biomolecules, which can be used to template the polymerization of synthetic macromolecules. Here, we highlight the control over the size, composition, and sequence one can nowadays obtain by using this methodology. We also highlight how templated processes exploiting dynamic covalent polymerization can, in return, result in therapeutic nucleic acids fabricating their own dynamic delivery vector – a biomimicking concept that can provide original solutions for gene therapies.