Exploring the biological mechanisms of obesity affecting breast cancer from a multidimensional perspective

Abstract

Obesity, a global health challenge, significantly contributes to breast cancer pathogenesis through chronic inflammation and metabolic dysregulation. This review summarizes the biological mechanisms through which obesity influences the development and progression of breast cancer, focusing on endocrine regulation, intercellular communication, gut microbiota interactions, obesity-associated genetic polymorphisms, and circadian rhythm homeostasis. The aim is to provide a theoretical foundation for the diagnosis and treatment of obesity-related breast cancer.