Abstract
A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [18F]KF to access 18F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[18F]fluorophenylalanine and 6-[ 18F]fluoroDOPA. © 2014 American Chemical Society.
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CITATION STYLE
Ichiishi, N., Brooks, A. F., Topczewski, J. J., Rodnick, M. E., Sanford, M. S., & Scott, P. J. H. (2014). Copper-catalyzed [18F]fluorination of (Mesityl)(aryl)iodonium salts. Organic Letters, 16(12), 3224–3227. https://doi.org/10.1021/ol501243g
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